Vitamin E and the mineral selenium do not prevent prostate cancer, according to a large study funded by the U.S. National Institutes of Health. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was halted early after a preliminary analysis of the data showed that these supplements, taken alone or together, did not reduce prostate cancer risk among more than 35,000 men age 50 and older who were studied.

Of more concern, the study suggested that the two supplements may carry an increased risk to men’s health: men who were taking only vitamin E showed a small increase in the number of prostate cancer cases, and those taking only selenium had a slight increase in the incidence of diabetes. However, these findings are still preliminary and they were not statistically significant, meaning that they could have been caused by chance.

Study participants are being notified by a letter that they should stop taking the supplements but will continue to have their health monitored for about three more years.

The findings are a major disappointment after previous studies suggested that Vitamin E might lower prostate cancer risk by more than 30 percent and selenium by over 50 percent. A drug called finasteride that is currently used to treat an enlarged prostate and male pattern baldness was recently shown to reduce the incidence of prostate cancer by 25 percent, but is not currently approved by the FDA as a preventative agent.

The doses involved in the study were higher than what is found in a typical multivitamin: 400mg/day vitamin E (the recommended daily intake is 15mg) and 200mcg/day selenium (U.S. RDI is 50-75mcg).

If you are currently taking daily vitamin E or selenium supplements, talk to your doctor about the risks and benefits of continuing their use. Or ask the health experts on Healia Health Communities.

_{Photo: Twenty Questions, Flickr, Creative Commons}