A follow-up study in Washington shows that although migraines are a real pain, they may spell relief for women at risk for developing breast cancer.

Dr. Christopher I. Li, M.D., Ph.D., of the Fred Hutchinson Cancer Research Center in Seattle, Wash. originally conducted this study with colleagues in 2008. Their original study linked clinically diagnosed migraines with a lower risk for both invasive ductal and invasive lobular breast cancer.

Breast cancer and migraines are both hormonally related conditions—migraines often resulting from unstable or changing hormone levels, especially estrogen. For women, who are 2-3 times more likely to experience migraines than men, this time is typically during the early days of menstruation.

The study found that postmenopausal women with a history of migraines had 32-33% reduced chance of developing breast cancer. These statistics proved to be even more consistent in subtypes of breast cancer that are estrogen-receptor and progesterone-receptor positive.

When the original study results were released last fall, the sample group consisted of roughly 3,500 postmenopausal Seattle women between the ages of 55-74. This time, however, Dr. Li and his colleagues were able to paint a much better picture. “Having a larger and more diverse study in its underlying population helps in replicating the findings,” Li says.

By more than doubling the sample size, expanding testing to women of different menopausal stages  (this time including ages 35-64), and adding four locations in Detroit, Los Angeles, Atlanta, and Philadelphia, researchers were able to define breast cancer’s connection to migraines more clearly.

In addition to age and menopausal status, many breast cancer risk factors also trigger migraines. Such factors include smoking, alcohol consumption and use of exogenous hormones (such as birth control). These risk factors, however, did not increase the likelihood of women with a history of migraines.

According to the second study, rates among the control and case groups were relatively unchanged, despite differences in use of prescription migraine medications and age at migraine diagnosis. Even among those who did not avoid these triggers, women with a history of migraines were still 26% less likely to develop breast cancer than those without.

It is not clear how migraines “protect” against breast cancer, but researchers hope to further examine the role of hormones, NSAIDs (nonsteroidal anti-inflammatory drugs) and other medications in the development of breast cancer.

The best way to reduce breast cancer risk is to check regularly. For more information on breast cancer and how to do a self-examination, visit NationalBreastCancer.org.

You can also check out Helia's  Breast Cancer Community!

 

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