Two new studies of human rhinovirus (HRV), the common cold,
have welcomed a new cold bug to the family. Previously, there were only two
known species of the virus—HRV-A and HRV-B. Now a third, HRV-C, can be added to
the list.
The HRV-A and HRV-B species alone represent different
strains of the virus, 99 to be exact. What’s surprising is that HRV-C, which
has an additional seven strains, appears to be a hybrid of both.
Researchers of the first study discovered the new species
while doing genome sequences for all 99 strains of the original HRV set. Genome
sequencing allows scientists to break down and more closely examine a virus’
RNA to find different combinations of genetic material.
When a person carries two strains of a virus, the strains
can come together to exchange this material, a process called recombination.
Because the new species shares characteristics of both HRV-A and HRV-B,
researchers have concluded that it is possible for a person to carry both
strains at once. So yes, you can have two colds at once.
“Coinfection with multiple HRVs is known to occur,” authors
of the second study write, “We now know that this can lead to strains that may
have distinct biologic properties and clinical characteristics.”
The second study examined 64 Chinese children, many of whom had
what they called a “triple infection.” Many had a form of rhinovirus and
another respiratory virus (such as the flu), but some had two rhinovirus
strains in addition to another respiratory virus.
When the body hosts a cocktail of viruses, this makes it
easier for different strains to exchange RNA and multiply quickly. Further
investigation suggests that there may actually be another species of the cold
on the way—HRV-D.
Researchers of the second study plan to continue exploring
HRV genetic material, and hope this will help lead to better treatment and more
effective medications.
“The clustering of small clades (biological groups), the
recombinations, and the mutations found in all regions of these genomes suggest
that future HRV epidemiologic studies might benefit from full genome sequencing
rather than the more limited serotyping,” they say.
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