Health news, tips and features: Healia Health Blog

January 2009

January 30th, 2009

The Top 10 States with the Lowest Rates of Smoking-Related Deaths

Deaths due to cigarette smoking have declined since the 1960s thanks to a parallel decline in smoking rates. When the Surgeon General first reported that smoking may be hazardous to your health in 1964, about 42 percent of American adults smoked. The most recent data available show that this rate has now dropped below twenty percent (19.8%) for the first time on record. The Centers for Disease Control and Prevention’s Smoking-Attributable Mortality, Morbidity, and Economic Costs report shows that overall death rates from smoking declined in all but one state (Oklahoma) between 1996-1999 and 2000-2004. Below is a list of the states with the lowest rates of smoking-related deaths, followed in parentheses by the smoking-attributable death rate per 100,000 residents and the percent change in that death rate between 1996-1999 and 2000-2004.

The top 10 states with the lowest rates of smoking-related deaths for 2000-2004 are:

  1. Utah (138.3 deaths per 100,000 residents, -11.0% change)
  2. Hawaii (167.6, -28.0%)
  3. Minnesota (215.1, -14.4%)
  4. North Dakota (225.6, -10.9%)
  5. New Mexico (234, -21.1%)
  6. California (235, -37.8%)
  7. Nebraska (235.8, -25.9%)
  8. Idaho (237.4, -21.5%)
  9. Colorado (237.6, -24.3%)
  10. Connecticut (238.3, -18.4%)

To find out more about lung diseases related to smoking, visit the Healia Health Community for Lung Diseases. Find help and support to quit smoking at the Healia Health Community for Smoking.

Source: Adhikari B et al "State-specific smoking-attributable mortality and years of potential life lost-United States 2000-2004" MMWR 2009; 58:29-33. http://www.cdc.gov/MMWR/preview/mmwrhtml/mm5802a2.htm

Photo: Paraflyer, Flickr, Creative Commons

January 30th, 2009

The Top 10 Worst Cities in the U.S to Live in with Asthma

For the past six years, the Asthma and Allergy Foundation of America (AAFA) has evaluated conditions in the 100 largest cities in America and ranked them based on the quality of life each affords for people with asthma. Researchers at AAFA review 12 factors that impact the quality of life for people with asthma, including: the crude death rate for asthma; the estimated prevalence of adult and pediatric asthma; risk factors, such as air pollution, pollen counts and public smoking; and medical factors, such as the number of asthma medications used per patient and the number of asthma specialists in the area. Below is a list of the cities that rank worst in quality of life for people with asthma in 2009.

This year’s top 10 worst cities in the U.S. to live in if you have asthma are:

  1. St. Louis, MO. This Midwest city tops the list this year after coming in ninth last year, due to a variety of factors, including poor air quality and a rise in the percentage of uninsured residents.

  2. Milwaukee, WI. Climbing up one spot from last year, Milwaukee has rates of self-reported asthma and estimated asthma prevalence that are higher than average, poor air quality, and only below average use of asthma control medications.

  3. Birmingham, AL. Jumping all the way up from number 13 on the list last year, Birmingham saw an increase in estimated asthma prevalence and ranks poorly in air quality and public smoke free laws. In fact, all of the cities that make the top 10 lack public smoking bans.

  4. Chattanooga, TN. Rising twelve spots from last year, this Appalachian city saw an increase in the crude asthma death rate and a decline in the use of rescue medications from last year. Chattanooga also ranks below average in air quality.

  5. Charlotte, NC. While this Southern city has an above average rate of estimated asthma prevalence, Charlotte saw a jump in its annual pollen score, which accounts for its rise from last years position in the number seven spot.

  6. Memphis, TN. A small bright spot on the list, Memphis improved in self-reported asthma incidence, annual pollen score, and uninsured rate from last year, causing it to drop one spot from last year’s list. High crude death rates from asthma and poor air quality still negatively impact people living with asthma in Memphis.

  7. Knoxville, TN. Home to the University of Tennessee, Knoxville improved its ranking considerably over last year when it held the top spot. Knoxville improved because both the estimated and self-reported prevalence of asthma decreased, and reported pollen levels were lower than the national average. However, poor air quality and low adherence to asthma medications keep Knoxville in the top 10.

  8. McAllen, TX. Perhaps not a household name, this border town near Brownsville jumps all the way up from number 26 last year. While the air quality ranking actually improved from last year, increases in the estimated and self-reported asthma prevalence and the annual pollen score are responsible for the precipitous rise.

  9. Atlanta, GA. The "Jewel of the South" improved its ranking from last year, moving down from the number four spot thanks to improvements in crude asthma death rate, poverty rate, rate of uninsured people, and use of quick-relief asthma medications. Below average air quality and low numbers of asthma specialists are still a problem in Atlanta.

  10. Little Rock, AK. Rounding out the top 10, Little Rock rose 12 spots from last year to just make the list. Increases in the annual pollen score, air pollution levels, and self-reported asthma rates offset a nice improvement in crude asthma death rate.

No matter where you live, having asthma that is uncontrolled can significantly impact your life and lead to missed school or work, emergency room visits, hospitalization, and even death. If your asthma is poorly controlled, talk to your doctor about making changes to your asthma action plan include adjustments in your current asthma prevention medications. Not sure if your asthma is well controlled? Take the Asthma Quiz Challenge and find out how much you know about uncontrolled asthma symptoms. Learn more by reading the Healia Health Guide to Uncontrolled Asthma.


Source: Allergy and Asthma Foundation of America, Asthma Capitals 2009, Jan 2009. http://www.aafa.org/pdfs/2009ACPublicList.PDF

Photo: IllinoisHorseSoldier, Flickr, Creative Commons

January 29th, 2009

5 Tips for a Super Safe and Healthy Super Bowl Party

This Sunday, with millions of people attending Super Bowl viewing parties in homes, bars, and restaurants across the country, safety and health should be a primary concern. With so many people heading out to parties, the roads can be a hazardous place to be both before and after the big game. The living room can also be hazardous for kids and pets when it is full of raucous partygoers. Also, Super Bowl gatherings often provide the opportunity to eat and drink too much. The Centers for Disease Control and Prevention (CDC) has come up with a list of 5 tips to help ensure your Super Bowl Sunday is a safe and healthy one.



  1. Eat healthy. If you are attending a Super Bowl party, it is a good idea to eat a healthy meal before you go. That way you won’t be tempted to snack throughout the long game or to overindulge in unhealthy foods. If you are hosting the party, include some healthy snack and entrée options. You can still serve the traditional typical pizza, wings, and chips, but try including some fresh fruits and vegetables, such as apples or carrot sticks, and food and options that are low in sugar and fat, such as "baked" potato chips, low-fat dips, and pretzel sticks. You can also offer low-fat beverage options such as coffee, tea, and fruit drinks.

  2. Limit alcohol. If you are a partygoer, avoid overindulging in alcoholic beverages before, during, and after the game. Moderate alcohol consumption may be fine, as long as you are not driving. Plan ahead and designate a non-drinking driver before the party begins. If you are a host, take steps to make sure that all your guests avoid driving under the influence of alcohol. Remind your guests to plan ahead and designate their sober driver. Offer alcohol-free beverages. Take responsibility and make sure all of your guests leave with a sober driver.

  3. Move around. If you watch the pre-game, game, and after-celebration, you will spend eight hours or more sitting. Make sure to include some physical activity during the day. You don’t necessarily need to go for a two mile run a halftime, just try to include some activities that raise your breathing and heart rate. Play a game of touch football during pregame or at halftime. Take a brisk 10 minute walk. Go up and down the stairs a few times. Anything to get you moving around.

  4. Stay warm. Many parts of the country are pretty chilly right now. If it’s going to be cold where you are, take steps to stay warm, especially if you have to be outdoors for any length of time. Dress warmly wearing loose-fitting layers that you can easily remove if you get hot. Drink warm liquids that don’t contain caffeine or alcohol, which tend to dehydrate you. Contrary to popular belief, alcohol does not warm you up; instead it actually causes your body to lose heat more quickly. When using a heat sources such as a radiator or space heater, make sure it is at least three feet away from furniture and drapes.

  5. Be careful. Injuries can easily occur to adults or children if you are not paying attention. Parties and tailgating can be fun, but it’s important to pay close attention to things that may cause injury. Take precautions to help prevent unwanted contact (physical, emotional, or sexual) between individuals. Watch the kids: DO NOT leave children unattended. Make sure your pets can handle the excitement before placing them in new or strange situations. If not, keep them in a safe place away from the noise, but make sure they have adequate food and water and that they get an opportunity to go to the bathroom. Never use generators, grills, camp stoves, or other or other combustible heat source indoors. Have a first-aid kit in your home and vehicle to handle injuries, like small cuts and bruises. Be especially careful when playing with children, particularly if you have been drinking.

Enjoy the game!

Have questions about party safety or other health issues? Ask the Experts at Healia Health Communities.


Source: CDC Office of Women's Health, modified January, 2009. http://www.cdc.gov/men/superbowl/index.htm

Photo: Alissa Gail Oakley, Flickr, Creative Commons

January 29th, 2009

Study Shows Kidney Donors Live Full Healthy Lives

A large study of the long-term effects of kidney donation finds that kidney donors can expect to live full, healthy lives in most cases. The retrospective analysis reported in today’s New England Journal of Medicine concludes that people who donate one of their two kidneys have a long term survival rate similar to non-donors and do not face increased risk of kidney failure.

Researchers at the University of Minnesota examined data from nearly 3,700 people who had donated a kidney at the university since 1963. They tracked down as many surviving donors as they could and used government records in an attempt to determine who had died. They randomly selected 255 donors to undergo tests of kidney function.

The results showed that the survival of kidney donors was similar to that of the general population when matched for age, sex, and race or ethnic group. Kidney failure requiring dialysis or transplant developed in 11 donors, which translates to a rate of 180 cases per million people per year. This is actually lower than the rate in the general population of 268 per million per year. The researchers noted that most donors who were studied enjoyed an excellent quality of life.

One of the main reasons for the good outcome for donors may have been the strict criteria in place for kidney donation. Donors had to be in good health and free of high blood pressure and diabetes, two of the main contributing factors for kidney disease. There are no official regulations regarding living kidney donation but most transplant centers adhere to similar criteria.

A scientist not involved in the study notes the donors were mostly young and mainly white. It remains to be seen whether the safety of living kidney donation holds for older, non-white donors. The University of Minnesota is part of an ongoing study that will examine a larger and more diverse donor group.

Most people are born with two kidneys, which function to eliminate waste from the body in form of urine. If someone’s kidneys fail the only options for survival are dialysis or a transplant. More than 78,000 people are currently on the national waiting list to receive a kidney from a deceased donor. Due in part to new surgical techniques that have shortened recovery times, living kidney donation has become more common in recent years. Lving donors must be tissue matched to recipients in order to be able to donate a kidney.

To find out more about living kidney donation, visit the Organ Procurement and Transplantation Network Web site or the National Kidney Foundation Web site.

If you want to learn more about kidney failure, join the Healia Health Community and Support Group for Kidney Failure. For information about type 2 diabetes, see the Healia Health Community for Diabetes Type 2 or read the Healia Health Guide on Diabetes Type 2.


Photo: shanelkalicharan, Flickr, Creative Commons

January 28th, 2009

5 Healthy Recipes for Super Bowl Party Dips and Appetizers

Super Bowl Sunday is the ultimate occasion for a house party. But what kind of food do you serve your hungry football-fan guests? Greasy chips and bean dip? No thanks. The Centers for Disease Control and Prevention (CDC) has compiled a list of healthy, low-fat recipes that contain fruits and vegetables. Fruits and vegetables are low in fat and contain essential vitamins, fiber, and other nutrients that may reduce your risk for many chronic diseases, including heart disease and certain cancers.

Try some of these healthy and delicious recipes for appetizers and dips that will impress even your most demanding and hungry football fans. This way, your guests can sit around all day watching football and eating without being penalized for excessive calorie consumption.

Tortilla Pizzas

Recipe Summary:
Preparation Time: 20 minutes
Number of Servings: 6
Cups of Fruits and Vegetables Per Person: 1.00

Ingredients:

  • 12 small corn or flour tortillas
  • Vegetable oil or margarine
  • 1 (16oz) can refried beans
  • 1/4 cup chopped onion
  • 2 ounces fresh or canned green chili peppers, diced
  • 6 Tbsp red taco sauce
  • 3 cups chopped vegetables, such as broccoli, mushrooms, spinach, and bell peppers
  • 1/2 cup (2oz) shredded part-skim mozzarella cheese
  • 1/2 cup chopped cilantro (optional)

Directions:
Brush one side of each of two tortillas with water. Press the wet sides of the tortillas together to form a thick crust for the pizza. Brush the outside of the tortillas with a small amount of oil or margarine. Evenly brown both sides in a heated frying pan. Repeat with the rest of the tortillas. Set aside. Heat refried beans, chopped onion, and half of the diced chili peppers together in a medium saucepan, stirring occasionally. Remove from heat. Spread about 1/3 cup of the bean mixture on each tortilla pizza. Sprinkle with 1 tablespoon of taco sauce, then top with 1/2 cup of the chopped vegetables, 1 teaspoon of diced chili peppers, and 1 tablespoon of shredded cheese for each pizza. Return to frying pan and heat until cheese melts. Top with cilantro, if desired. Serve immediately.

Cranberry Salsa

Recipe Summary:
Preparation Time: 10 minutes
Number of Servings: 8
Cups of Fruits and Vegetables Per Person: 0.50

Ingredients:

  • 4 oz 100% cranberry juice blend
  • 1-1/2 cups diced tomatoes
  • 1 cup fresh cranberries, sliced thin
  • 1/4 cup ripe medium avocado, diced
  • 1/2 cup diced pineapple
  • 1/2 cup thinly sliced scallions (including green tops)
  • 2 Tbsp lemon juice
  • 1/4 cup finely chopped jalapeno peppers
  • 2 cloves crushed garlic (about 1 tsp)
  • fresh ground pepper, as desired

Directions:
Place juice into a saucepan. Boil for about 5 minutes until reduced to about 1 Tbsp of syrup. Place the reduced juice and all remaining ingredients into a medium bowl and stir until incorporated. Chill and serve immediately with favorite chips and vegetables. * Fresh cranberries may be stored in your freezer for up to 1 year.

Cucumber Yogurt Dip

Recipe Summary:
Preparation Time: 15 minutes
Number of Servings: 6
Cups of Fruits and Vegetables Per Person: 0.50

Ingredients:

  • 2 cups plain low-fat yogurt
  • 2 large cucumbers, peeled, seeded, and grated
  • 1/2 cup nonfat sour cream
  • 1 Tbsp lemon juice
  • 1 Tbsp fresh dill
  • 1 garlic clove, chopped
  • 1 cup cherry tomatoes
  • 1 cup broccoli florets
  • 1 cup baby carrots

Directions:
Peel, seed, and grate one cucumber. Slice other cucumber and set aside. Mix yogurt, grated cucumber, sour cream, lemon juice, dill, and garlic in a serving bowl. Chill for 1 hour. Arrange tomatoes, cucumbers, broccoli, and carrots on a colorful platter. Serve with cucumber dip.

Bruschetta with Plums and Fresh Basil

Recipe Summary:
Preparation Time: 30 minutes
Number of Servings: 6
Cups of Fruits and Vegetables Per Person: 1.00

Ingredients:

  • 1 sourdough baguette (24 inch)
  • 4 oz fat-free cream cheese, whipped
  • 6 cups sliced fresh California plums
  • 1 cup fresh basil

Directions:
Slice baguette into 24 inch-thick pieces. Toast in a 350°F oven until golden brown. Spread each slice of bread with fat-free cream cheese. Slice plums into thin slices. Place several slices of plum on each piece of bruschetta. Garnish with fresh basil leaf

Avocado Green Onion Party Dip

Recipe Summary
Preparation Time: 30 minutes
Number of Servings: 7
Cups of Fruits and Vegetables Per Person: 0.50

Ingredients:

  • 1/2 medium avocado, seeded and peeled
  • 1 cup low fat cottage cheese
  • 3/4 cup plain, non-fat yogurt
  • 1/2 cup sliced green onions
  • 1/4 cup shredded carrots
  • 1 Tbsp fresh lemon juice
  • 1/4 cup non-fat mayonnaise
  • 2 cups broccoli florets
  • 1 cup cucumber slices
  • 28 melba toast rounds

Directions:
Dice avocado into small pieces, toss with lemon juice and set aside. In food processor or blender, blend cottage cheese, yogurt and mayonnaise until smooth. Add cottage cheese mixture to avocado, gently stirring in onions and carrots. Cover and chill. Serve with vegetable crudités and melba toast rounds, allowing ½ cup vegetables, 4 melba toast rounds and 8 Tbsp dip per serving.


Source: Centers for Disease Control and Prevention, www.fruitsandveggiesmatter.gov
Photo: David Hudson Floyd, Flickr, Creative Commons

January 28th, 2009

Impact of Sports Concussions among Athletes Lasts 30 Years

Canadian researchers report today that athletes who suffer a concussion while playing sports continue to show negative effects of their injury 30 years later. The results are alarming because until recently, most research into the aftereffects of concussions has focused on the period immediately following the injury or at most a few years after.

Researchers at the Université de Montréal gave a questionnaire to former university-level athletes (mainly hockey players) who are now in their 50s and asked them if they had ever suffered a concussion during their playing days. The researchers identified a group of 19 healthy former athletes who had sustained concussion more than 30 years ago and another group of 21 healthy former athletes with no history of concussion. When compared, the results showed that former athletes who had suffered only one or two concussions showed declines in their attention and memory, as well as a slowing of movements compared to athletes who had not suffered a concussion.

Specifically, former athletes who had suffered a concussion more than 30 years ago (and not since) showed signs of mild cognitive impairment on the Mini-Mental Status Examination (MMSE), which tests orientation, attention, immediate and short-term recall, language, and the ability to follow simple verbal and written commands. They also showed deficits on tests of episodic memory and executive function. Electroencephalogram (EEG) tests showed impairments in brain activity as well: concussed participants showed aberrant responses to unpredictable stimuli. Even their overall movements were slower than their non-concussed counterparts.

The results of the study are alarming on several levels. For one, they call into question the current thinking about sports concussions, which is often focused on ensuring safety by determining how much time should pass after a concussion before an athlete returns to competition. The results also indicate that sports concussions may actually accelerate the aging process in the brain, perhaps making these athletes more vulnerable to developing severe neurological disorders including dementia, Alzheimer’s disease, and Parkinson’s disease.

However, it is important to note that all the study participants were all still fit and healthy and continued to engage in some form of regular physical activity at least three times a week. They lived relatively normal lives despite their mild impairments. The researchers intend to follow the participants in the coming years to determine if they experience more severe deteriorations in their mental functioning and quality of life.

The researchers suggest that athletes should be better informed about the long-term effects of sports concussion on mental and physical functioning so that they can weigh the potential risks of returning to competition after a concussion.

Do you have child who plays contact sports? If he or she experiences an on-field concussion, you may want to consider talking to the doctor about the risks of a return to competition. For more information about concussions, join the Healia Health Community for Head and Brain Injuries.


 

Photo: JamieL.WilliamsPhotograph y, Flickr, Creative Commons 

January 27th, 2009

Inherited Differences may Determine Response to Treatment for Childhood Cancer

Researchers from St. Jude Children’s Research Hospital in Memphis, Tenn. report that inherited genetic differences may help determine how well children with a specific type of blood cancer will respond to treatment. A study in the January 28th issue of the Journal of the American Medical Association links differences in more than 100 genetic markers with the response to chemotherapy treatment in children with acute lymphoblastic leukemia (ALL), the most common type of childhood cancer.

Understanding inherited genetic differences in the response to cancer can help doctors understand why treatments fail on some patients and lead to better treatment strategies, such as determining at the outset which patients may require more aggressive treatment. It may also help researchers develop new ways of treating patients such as drugs that mimic the genetic variations associated with better treatment responses.
 
While the survival rate for ALL has climbed from less than 10 percent in the 1960s to over 80 percent today, there is still considerable variation in how individual patients respond to treatment for the disease. To find out why, researches examined variations in the inherited genetic make-up of children undergoing treatment for ALL and compared these to the number of cancer cells left over after the first course of chemotherapy (known as the minimal residual disease). More than 100 variations called single nucleotide polymorphisms (SNPs) were found to be associated with differences in treatment outcome.

About 20 percent of the markers were related to a tendency for relapse, and a similar number of markers were associated with a very strong, early response to treatment. In addition, 20 percent of the markers were associated with how the body responds to chemotherapy drugs used to treat leukemia. Gene variations associated with faster elimination of the drugs from the body were associated with worse treatment outcomes, suggesting that patients with these variations may only need a higher dose of chemotherapy to achieve the same result as other patients.

The researchers also found that variations associated with the gene for a molecule called interleukin 15 (IL15) already known to protect certain tumors from chemotherapy drugs was associated with higher levels of this of this molecule in leukemia cells, and a poorer outcome after therapy.

The study is unique in that most research into the genetics of cancer treatment focus on acquired variations in cancer cells that occur only after birth and affect only the cancer cells themselves. The present study looked instead at variations in the inherited genetic profile that are present from before birth and found in every cell of the body.
 
While the results of the study are encouraging, it may be a while before genetic testing of cancer patients to determine treatment strategies becomes common. Researchers need to verify that the genetic differences really do equate to differences in long-term survival, but if so, expect to see other researchers using similar methods to study the association between genetic variations and treatment response in other cancers.

For more information about ALL and cancers of children, join the Healia Health Community for Childhood Leukemia or the Healia Health Community for Childhood Cancer.

Photo: VashiDonsk, Wikimedia Commons, GNU Free Documentation License

January 27th, 2009

The Top 10 Cities with the Cleanest Air in America

The State of the Air report is an annual publication of the American Lung Association (ALA) that ranks cities and counties based on their levels of air pollution. The following is a list of the cleanest cities for air pollution from that report, based on the annual PM2.5 concentration, a measure of the yearly concentration of particles in the air that are less than 2.5 micrometers in size (PM2.5), which are thought to be the most harmful to human health. The ALA used the Environmental Protection Agency’s database to obtain the data, calculated the concentration of a pollutant, and ranked cities based on the EPA’s determination of the number of days that violated the national ambient air quality standard for annual PM2.5 of 15 µg/m3. The list below represents the cities with the best annual PM2.5 measures over the years 2004-2006 followed in parentheses by the total population that inhabits each area. Note that mostly small and medium-sized cities make the list.

The top 10 cities with the cleanest air in the U.S. are:

  1. Cheyenne, WY (85,384)
  2. Santa Fe-Espanola, NM (183,356)
  3. Honolulu, HI (909,863)
  4. Great Falls, MT (79,385)
  5. Farmington, NM 126,473
  6. Tucson, AZ (946,362)
  7. Bismarck, ND (101,138)
  8. Flagstaff, AZ 124,953
  9. Anchorage, AK (359,180)
  10. Salinas, CA (410,206)

To find out more about diseases caused by air pollution, join the Healia Health Community for Lung Diseases or the Healia Health Community for Heart Diseases.

Related blog posts: Study Finds Cleaner Air Lengthens American Lives by Nearly Five Months

        The Top 10 Most Polluted Cities in America



Source: American Lung Association, State of the Air 2008, Table 2. http://www.stateoftheair.org/2008/key-findings/SOTA08_Table2.pdf

Photo: Reba Rear, Flickr, Creative Commons
January 23rd, 2009

The Top 10 States with the Highest Rates of Smoking-Related Deaths

Smoking rates—and smoking-related deaths—have declined pretty steadily in the United States since a 1964 Surgeon General’s report that suggested smoking may be hazardous to your health. At that time, around 42 percent of American adults smoked. The latest data from the Centers for Disease Control and Prevention (CDC) show that for the first time on record, the smoking rate among U.S. adults has dropped below twenty percent (19.8%). In the CDC's Smoking-Attributable Mortality, Morbidity, and Economic Costs report, the agency reports that overall deaths rates from smoking declined in all but one state between 1996-1999 and 2000-2004. However, the smoking death rate actually increased for women in several states, and many states still have relatively high rates of smoking-related deaths. Below is a list of the states with the highest rates, followed in parenthesis by the smoking-attributable death rate per 100,000 residents and the percent change in that death rate between 1996-1999 and 2000-2004.

The top 10 states with the highest rates of smoking-related deaths for 2000-2004 are:

  1. Kentucky (370.6 deaths per 100,000 residents, -13.3% change)
  2. West Virginia (344.3, -21.5%)
  3. Nevada (343.7, -44.4%)
  4. Mississippi (333.6, -9.4%)
  5. Oklahoma (332.1 +26.9%)
  6. Tennessee (325, -12.4%)
  7. Arkansas (323.7, -9.8%)
  8. Alabama (317.5 -5.9%)
  9. Indiana (308.9, -14.4%)
  10. Missouri (307.8, -27.3%)

To find out more about lung diseases related to smoking, visit the Healia Health Community for Lung Diseases. Find help and support to quit smoking at the Healia Health Community for Smoking.

Source: Adhikari B et al "State-specific smoking-attributable mortality and years of potential life lost-United States 2000-2004" MMWR 2009; 58:29-33. http://www.cdc.gov/MMWR/preview/mmwrhtml/mm5802a2.htm

Photo: Saudi..., Flickr, Creative Commons

January 23rd, 2009

FDA Approves First Trial Using Human Embryonic Stem Cells

The Food and Drug Administration (FDA) announced today that it has approved the first clinical trial ever to test the use of human embryonic stem cells. The landmark experiment will test the safety and effectiveness of using embryonic stem cells to treat patients with recent spinal cord injuries.

The small phase I trial will involve giving a single injection of embryonic stem cells to eight to ten paraplegic patients within two weeks of suffering a spinal cord injury that leaves them with no sensation or movement in the legs. Prior to injection, the stem cells will be manipulated to become immature oligodendrocytes, cells that, when mature, insulate nerve cells and stimulate their growth. Previous studies conducted in animas have demonstrated the ability of these cells to regenerate nerve tissue.

The trial is to ensure the safety of the technique in humans, but the researchers will also be looking for improvements in function, such as the return of feeling or movement in the legs.

The study will be conducted by a biotechnology company at four to seven yet-to-be-determined sites around the country. After receiving an injection of stem cells at the site of their injury, patients will be given anti-rejection drugs for the first two months to prevent immune rejection of the cells. Researchers believe that anti-rejection treatment will not be necessary beyond this period.

The new study will be watched closely as it is the first to really test the potential of embryonic stem cells, which have been touted as a possible cure for everything from Parkinson’s disease to diabetes. Previous experiments have used adult human stem cells to treat such conditions as heart attack, but these cells are much more limited in their potential for repair. The promise of embryonic stem cells is that the cells can be coaxed into becoming literally any cell type in the body, from brain cells to insulin-producing cells in the pancreas.

Embryonic stem cells are controversial because they can only be obtained through the destruction of very early-stage human embryos. Former President Bush had restricted government funding of embryonic stem cell research to projects using embryonic stem cell lines that already exist. President Obama has pledged to amend that practice, but the FDA says that the decision to approve the present study was completely unrelated to the recent political change. The research plan for the study was drawn up before the election, uses stem cells already in existence, and did not rely on any federal funding.

For more information on coping with spinal cord injury or to share your thought on the announcement of this landmark study, join the conversation at the Healia Health Community for Spinal Cord Injuries and Diseases.


Photo: Ed Yourdon, Flickr, Creative Commons

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