High cholesterol refers to high levels of cholesterol in the blood that can increase your risk of heart disease.
Roughly 120 overweight or
obese patients from the Department of Veterans Affairs clinics in Durham, N.C.,
volunteered for a study comparing the effects of two different dieting
plans—the low-carb, ketogenic
diet (LCKD) and a low-fat diet in combination with orlistat
(LFD+O), a weight-loss medication.
Sixty-five of the volunteers completed the low-fat
diet, eating a diet with less than 30 percent of energy intake from fat and
taking 120 mg of orlistat three times daily. Orlistat (Alli, Xenical) is an
over-the-counter weight loss aid that can block a significant amount of fat
from being absorbed by the digestive system. At the end of the 48-week trial,
the group cut 8.5 percent of body fat. Low-carb
dieters, on an Atkins-style
diet, had similar results, trimming 9.5 percent of body fat.
“Both groups lost
considerable weight (on average 21-25 pounds) and experienced numerous health
benefits and were able to reduce medications for chronic diseases associated
with weight,” explains Dr. William Yancy, Jr., M.D., research associate
at Durham’s Department of Veterans Affairs and lead author of the study.
Although both plans tied for
weight loss and had similar HDL (good cholesterol) improvements, the group of
57 low-carb dieters also had decreased systolic and diastolic blood pressure by
5.9 and 4.5 mm, respectively.
Pre-trial, average body
mass index (BMI) was 39.3, and one in three participants had type 2 diabetes.
A healthy BMI score for an adult ranges between 18.5 and 24.9. As the scores
rises, the risk for complications such as stroke, type 2
diabetes, poor cholesterol and heart disease
increases.
Following the study, low-fat
dieters enjoyed better LDL (bad cholesterol) levels, while participants on the
low-carb diet had improved insulin metabolism, hemoglobin A1C, and
blood glucose levels.
“People with these
diseases—hypertension, high cholesterol, diabetes, arthritis—or at risk for
these diseases stand to benefit the most (from these diets),” Yancy explains.
There haven't been significant health risks for short-term dieters, but little is known of the effects after six months. Long-term dieters may be at risk for bone loss or kidney stones. In any case, Dr. Yancy urges anyone considering a low-carb, ketogenic diet to consult a physician.
The study's abstract can be found in the Archives of Internal Medicine.
Dr. Ramón Estruch of the University of Barcelona’s
Department of Internal Medicine was the study’s senior author. Estruch and his
team asked 42 high-risk men and women age 55 or older to take part in an
experiment examining the effects of cocoa on heart disease.
“Cocoa and its derived products, such as chocolate,
represent a very rich source of dietary flavonoids, which contain a higher
content per serving than tea or red wine,” authors write. “The health benefits
associated with cocoa consumption have been related to their capacity to
improve the lipid profile and insulin sensitivity, diminish blood pressure,
reduce platelet activity and function, and ameliorate endothelial dysfunction.”
Participants were given two sachets of non-fat, sugar-free
Cola Cao, a popular Spanish cocoa powder mix similar to Nesquik. They were to
mix 20 g (about 1 ½ Tbs.) with 250 ml (~8.5 oz) of skim milk and drink twice
daily—once with breakfast, and again with dinner or an afternoon snack. All
participants followed a Mediterranean-style diet, but were asked to exclude
foods with cocoa, olive oil, red wine, tea, or fruits and vegetables with high
polyphenol levels.
Participants did have a slight weight gain of about 1 pound.
Total cholesterol and triglyceride levels were slightly (although not
significantly) lower. Cocoa did,
however, show anti-inflammatory effects. These were modest compared to those of
red wine, but significant nonetheless.
HDL (good cholesterol) levels were also significantly higher
after drinking chocolate milk.
“Our results suggest that regular consumption of nutritional doses of cocoa may have an effect on all initial phases of the atherosclerotic process in subjects at high risk of coronary heart disease,” authors wrote. “These anti-inflammatory effects, together with other previously reported effects, including those of antioxidant, anti-platelelet, and positive vascular effects, may contribute to the overall benefits of cocoa consumption against atherosclerosis.”
The study appears in the American Journal of Clinical Nutrition.
If you
have high cholesterol levels, the best way to lower it may be through changes
in your diet and activity level. Increasing your daily exercise can help
increase the levels of HDL
(the good cholesterol) in your blood. Decreasing your intake of saturated fats
is a good way to reduce your LDL
(the bad cholesterol) levels. Another way to help lower LDL levels is to eat
foods that promote lower cholesterol. When eaten as part of a balanced diet,
the five foods below can help you lower your bad cholesterol levels and may
help you avoid the need to take cholesterol-lowering medications.
For more information on how to help lower your cholesterol levels, join the conversation in the Healia Health Community for High Cholesterol. To connect with others who are interested in nutrition issues, join the Healia Health Community for Diet and Nutrition. Find out more about heart-healthy eating in the Healia Health Guide on Weight Management.
Source: Mayo Clinic, Cholesterol: The top 5 foods to lower your numbers, May 2008. http://www.mayoclinic.com/health/cholesterol/CL00002; International Food Information Council http://www.ific.org/publications/factsheets/sterolfs.cfm
Photo: avlxyz, Flickr, Creative Commons
A
new study has found that statin
drugs, normally prescribed for people with high cholesterol, may also reduce
the risk of heart attacks and strokes among those with low cholesterol levels
and no other major risk factors for heart disease.
The study participants all had normal levels of LDL cholesterol (“bad” cholesterol) but also had elevated levels of high-sensitivity C-reactive protein (CRP), an indicator of inflammation that may prove to be a good predictor of heart disease. About 4% of the adult population fits these criteria and may potentially benefit from use of statins. Researchers are unclear as to why statin drugs reduce disease risk in this population.
The study tracked more than 17,000 people in 26 countries and showed that people taking the statin drug Crestor (rosuvastatin) were 54% less likely to experience a heart attack, 48% less likely to have a stroke, and 20% less likely to die from any cause. The effects were seen across all subgroups, regardless of gender, race, weight, or other factors.
Statins are the world’s top selling class of drugs and include Crestor, Lipitor, Zocor, and generic versions. The study was paid for by AstraZeneca, the makers of Crestor.
This study provides some encouraging insight about the potential benefits of statins in people with low cholesterol. However, the costs of taking statin drugs, both in expense and potential side-effects, might outweigh any reductions in heart attack and stroke risk. To find out more, talk to your health care provider or ask the experts on Healia Health Communities. For more about heart disease, cholesterol, and CRP, see the Healia Health Guide on Heart Disease.
Photo: kk+, Flickr, Creative Commons
The American Heart Association (AHA) has proclaimed Friday, February 1, 2008 as National Wear Red Day to help increase heart disease awareness and support ongoing research/education about heart disease among women.
Protecting your heart early (as early as your 20s) may help reduce risk of cardiovascular disease. You can reduce the modifiable risk factors of heart disease by following the ABCs of Preventing Heart Disease, Stroke, and Heart Attack:
heart disease National Wear Red Day women heart disease
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