Researchers from Massachusetts General Hospital’s Center for Engineering cleared live cells from liver tissue to leave a framework. They “re-seeded” healthy liver tissue into the framework, where tissues eventually regenerated.

The goal is for the tissue to attach to host tissues, where it would take root and redevelop unhealthy tissue. Although experimentation is in its early stages, the method was successful in laboratory rats.

“As far as we know, a transplantable liver graft has never been constructed in a laboratory setting before,” lead researcher Dr. Korkut Uygun told BBC News.

If it proved effective in humans, it could be a realistic answer to the donor organ shortage. Roughly 15,000 people are in need of a new liver each year, while the actual number available is a mere 4,500. This method could help make previously rejected organs acceptable for transplant.

“We haven’t been able to go beyond several hours in the rats,” Uygun says, “but it’s a great start.”

Want to know more? See Uygun’s article in Nature Medicine.