Breast diseases can begin with a lump, pain, discharge, or skin irritation of or around the breast. Some common causes of breast changes are fibrocystic breast condition, fibroadenomas, intraductal papillomas, injury, blocked or clogged milk ducts, and cysts. Most women experience breast changes at some time.
Breast
cancer forms in the mammary glands and/or ducts. Tissues in these areas grow
and multiply at unregulated rates, forming tumors. The body recognizes these
tumors as healthy tissues and will not destroy them as it would a virus.
According to the Susan G. Komen Foundation, it could take as long as 10 years
before a tumor is large enough to detect.
Most
current efforts to treat breast cancer focus on how to destroy or stop the
growth of already-present cancer cells using tumor antigens. The problem is
that these methods essentially kill the tissues. It can also compromise the
autoimmune systems of already vulnerable cancer patients. The Cleveland Clinic's
vaccine takes a new approach: It’s designed to stop tumors before they’ve had a
chance to develop.
Lead
researcher Dr. Vincent Tuohy observed mice predisposed to breast cancer for 10
months. The vaccine targeted alpha lactalbumin, a specific protein found in
most breast cancer cells. Half of the mice were given the vaccine, while the other
half acted as a control group. At the end of the trial, none of the vaccinated
mice had developed breast cancer. All of unvaccinated mice had.
"We
believe that this vaccine will someday be used to prevent breast cancer in
adult women in the same way that vaccines prevent polio and measles in
children," Tuohy said in a Cleveland Clinic press release. "If it
works in humans the way it works in mice, this will be monumental. We could
eliminate breast cancer."
Although
there is still much more to investigate before the vaccine is ready for human
trials, the research team hopes to be able to administer the vaccine to women older
than 40 and women at high risk in the next 10 years.
Visit the
Cleveland Clinic’s website to read the press release,
or visit Nature Medicine to read the study’s abstract.
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